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Was Analyse Thrombophlebitis

Was Analyse Thrombophlebitis Treatment for superficial infusion thrombophlebitis of the upper extremity | Cochrane


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Thrombosis of superficial veins has long been regarded as a benign disorder. Treatment of patients' SVT with parenteral anticoagulants was Analyse Thrombophlebitis to be both efficacious and certainly safe. Systemic anticoagulant therapy of patients Genetische Analyse Thrombophlebitis a clinical diagnosis of SVT obviates extensive imaging and laboratory workup and may be cost effective while encompassing treatment of any unknown concomitant thromboses with only low risk for hemorrhage.

This decision is especially clear in those patients was Analyse Thrombophlebitis known hypercoagulability. Patients without clinical risk factors are at lower risk to develop VTE complications and might be those who can be simply observed.

The term VTE is also used to Genetische Analyse Thrombophlebitis thrombosis of the deeper veins of the upper extremities. Focusing on causes of hypercoagulability such as genetic hypercoagulability [thrombophilia], obesity, immobility, prolonged travel, inflammation, impaired blood flow, pregnancy, malignancy, trauma, surgery, and others emphasizes the prime role played by blood within the vessels rather than any major role played by anatomic location of the vessels.

Thus, causation and its major serious outcome fatal PE should be at the forefront in consideration for initiation of systemic anticoagulant therapy, was Analyse Thrombophlebitis.

The explanation may be historically based. Before modern biochemical explanations of hypercoagulability as well as the availability of modern imaging to diagnose even the deepest or most occult of venous thromboses, it was held that thrombosis of the superficial veins with particular reference to the great saphenous vein [GSV] was so easily identifiable that the diagnosis was Analyse Thrombophlebitis SVT was held separate and apart from the more occult and subtle DVT.

Extensive earlier medical literature subdivided SVT into primary inflammation of the venous wall leading to thrombosis Genetische Analyse Thrombophlebitis primary thrombosis leading to inflammation of the vessel wall, namely, phlebothrombosis versus thrombophlebitis, terms of which the meanings now are vague, hold little merit, and should be discarded.

Hematologists and internists did not participate in diagnosis and management of venous thrombosis to any extent until the second half of the last century; such was the purview of surgeons, was Analyse Thrombophlebitis.

Linkage of venous thrombosis to surgical procedures was clear, was Analyse Thrombophlebitis, and was Analyse Thrombophlebitis surgical techniques of thrombectomy and ligation of the thrombosed superficial vessels they diagnosed were considered state of the art.

Although therapy with either heparin or oral vitamin K antagonists was in the developmental stage, was Analyse Thrombophlebitis, there were no established or agreed-on guidelines for indications, dosage, intensity, monitoring, or duration for Genetische Analyse Thrombophlebitis of either anticoagulant.

Underanticoagulation with its resultant failure to control thrombosis or overanticoagulation with hemorrhagic complications were commonplace and indirectly served to impede their usage to their present place. This degree of disorganization persisted until the initiation of modern studies of dosage and duration of anticoagulant therapy along with the concept of evidence-based medicine, which essentially began with the seminal report of heparin's efficacy in more info of PE by Barritt and Jordan 3 and continues with the efforts initiated by Hirsh et al.

The experiential approach to Genetische Analyse Thrombophlebitis being limited only Genetische Analyse Thrombophlebitis what one saw and felt at the bedside is no longer appropriate or sustainable. Why clinicians continue to segregate SVT from all other venous thromboses is not readily explainable, particularly now that the experimental approach has become dominant and Genetische Analyse Thrombophlebitis and therapy are so effective.

If thromboses of the visceral, cerebral, renal, and pelvic veins fit well into our modern thinking of VTE, the time seems right to abandon anatomic location of a venous thrombosis as a special sanctuary having its own diagnostic niche, therapy, and separate clinical approach. This confusion Genetische Analyse Thrombophlebitis obfuscated review of the literature.

The preponderance of reports and data on SVT involve thrombosis of the long saphenous Genetische Analyse Thrombophlebitis, the longer proximal part of which is the GSV the now-preferred term and the smaller, more distal part, the lesser was Analyse Thrombophlebitis vein.

The time has come to eliminate this nomenclature; no reason to support retention of this misleading term has been advocated by any professional was Analyse Thrombophlebitis. Third, superficial veins also include the veins that occur anywhere superficially Genetische Analyse Thrombophlebitis the body whether they are on the abdominal wall, thoracic wall, or arms.

These painful thromboses may be collaterals of deeper occluded veins, such as Genetische Analyse Thrombophlebitis inferior vena cava or deep veins of the arm. That all was Analyse Thrombophlebitis terminologies, was Analyse Thrombophlebitis, incorrect usages of anatomic terms, and incomplete studies are confusing issues was deduced by the Cochrane Collaboration systemic review of SVT by DiNisio et al. They noted that, although SVT had long been regarded as a fairly benign disease, that stance has been increasingly called into question.

The few available studies are heterogeneous and descriptive in nature, was Analyse Thrombophlebitis, and follow-up of patients is so limited that meaningful recommendations cannot be gleaned was Analyse Thrombophlebitis the existing literature. Because most reports specifically excluded patients having known concomitant DVT and PE, excluded patients with prior DVTs and PEs, excluded those with family histories positive for DVT, and excluded those who had ever been treated with anticoagulant therapy, generalization of these data to one's own SVT patients may be flawed in that those results might be too benign as these real risk factors had been eliminated in read more study group.

These approaches are not compatible with our current view that VTE is best regarded was Analyse Thrombophlebitis systemic, was Analyse Thrombophlebitis, chronic, and often familial rather than isolated, acute, and random.

Using modern imaging techniques article source at the time of a clinical diagnosis, Chengelis et al 21 studied the progression of thrombosis between day 2 and day 10 average, 6. Recently, in a cross-sectional prospective cohort study, Decousus et al 24 prospectively described such data among SVT patients. Multiple studies written in Genetische Analyse Thrombophlebitis last decade have demonstrated enrichment of thrombophilia among patients diagnosed with SVT.

Among their strongest risk factors were the hypercoagulable states to include thrombophilia as well as malignancy. Other risk factors included aging and impaired blood flow from obesity, pregnancy, or even prolonged air travel. Heit et al 27 were the first to note that a prior history of SVT served as an independent risk factor was Analyse Thrombophlebitis the future development of Hausgemachte Rezepte Krampfadern, again linking etiology.

Their observation was Genetische Analyse Thrombophlebitis by Schönauer et al. There is no therapy for SVT that is agreed on and, given the wide variety of options and the lack of randomized clinical trials, one may deduce that a clear and effective evidence-based therapy is not currently available 14 Table 2, was Analyse Thrombophlebitis. Clinical observation coupled with strict bed rest with complete immobility was recommended in the past as therapy for SVT by many authorities.

Such passive therapy may have seemed effective in part because relief of pain and swelling generated by SVT was Genetische Analyse Thrombophlebitis predominant endpoint. Once serial measuring for either regression or progression of the SVT became available, first by venography and then by plethysmography and now by ultrasound, it was rational to observe patients for evidence of progression, treating with heparin only those who demonstrated progression.

There are still some patients for whom observation and serial ultrasounds every 5 to 7 days may be appropriate, was Analyse Thrombophlebitis, but these appear to be the minority of patients. These might include Genetische Analyse Thrombophlebitis patients in whom anticoagulant therapy might be effective yet pose excessive risk such as patients with severe thrombocytopenia or was Analyse Thrombophlebitis ongoing hemorrhage or patients perceived to be at lower risk for further thrombosis such as patients with no prior personal or family history of Genetische Analyse Thrombophlebitis and was Analyse Thrombophlebitis having no other clinical hypercoagulability risk factors, such as malignancy, immobilization, Genetische Analyse Thrombophlebitis concurrent inflammatory disease, was Analyse Thrombophlebitis.

Several reports have advocated that ultrasonographic imaging be routinely made for evidence of thrombosis more extensive than just the observable SVT, was Analyse Thrombophlebitis.

Such logic hinges on the belief that any thrombosis discovered above and beyond the SVT should be systemically treated, whereas those cases of SVT existing alone should not be systemically treated. That many patients' limited SVT might soon progress also implies that one must periodically reimage to observe for evidence of progression, was Analyse Thrombophlebitis. Many publications have also suggested was Analyse Thrombophlebitis laboratory searches for thrombophilia should be carried out, the logic Genetische Analyse Thrombophlebitis which is based solely on the concept that such findings would alone and critically change Genetische Analyse Thrombophlebitis therapeutic intent.

Were one rather to deduce that the SVT itself, whether alone or coexisting with other VTE, warranted anticoagulant therapy, complete initial imaging, serial imaging, and laboratory testing could be abrogated, was Analyse Thrombophlebitis, thus limiting expense. Any known or unknown coexisting thrombosis would be treated by incorporation if one selects to use systemic anticoagulant therapy of their SVT patients. Nonsteroidal Genetische Analyse Thrombophlebitis drugs have traditionally been used either orally was Analyse Thrombophlebitis topically, was Analyse Thrombophlebitis.

This approach seems to be in doubt because, even if inflammatory manifestations Genetische Analyse Thrombophlebitis SVT was Analyse Thrombophlebitis respond to either time, the administration of nonsteroidal anti-inflammatory drugs, or the combination, such symptomatic improvement does not necessarily indicate that clot progression has been mitigated.

The basis of this approach was that, if the proximal end of the clot approaches within a few centimeters of, click at this page alone passes into, the junction of the GSV with the femoral vein, the risk of possible embolism became serious enough to warrant surgical intervention, was Analyse Thrombophlebitis. Surgical approaches involved a variety of procedures, ranging from ligation of the GSV, surgical removal of thrombus in the GSV, surgical excision of the entire GSV, and multiple diverse surgical procedures.

To the extent that one thinks systemically especially with regard to causationone sees was Analyse Thrombophlebitis surgical approach has limited credibility.

Surgery itself serves an enormous impetus was Analyse Thrombophlebitis for additional thrombosis. Medical treatment is now recommended over surgical treatment. These reports used lower-than-therapeutic doses rather than commitment to full therapeutic dosage.

With those 2 limitations too low intensity for too brief a periodit remains surprising that Genetische Analyse Thrombophlebitis benefit was observed. The Cochrane Collaborative reviewers concluded that any treatment with any anticoagulant over any period of time not only seemed logical but resulted in trends toward efficacy.

Importantly, the Cochrane Was Analyse Thrombophlebitis reviewers documented negligible bleeding complications with anticoagulant therapy. The medical group received 4 weeks of moderately intensive enoxaparin therapy, whereas the surgical group underwent saphenofemoral surgical disconnection.

Their selection process excluded many patients who one sees in actual clinical practice, such as those patients with probable or known hypercoagulability, patients with known prior DVT and PE, patients with malignancy, and patients with renal failure. Patients were randomized between a prophylactic dose of fondaparinux 2. Patients were treated for 45 days the longest treatment group studied thus far and then followed for the subsequent 30 days off treatment.

The study showed that, at 45 days, the treatment group had developed the primary endpoint of progression of thrombosis at a rate of 0.

The fondaparinux group, compared with the placebo was Analyse Thrombophlebitis, experienced a significant decrease in PEs, DVTs, and SVT extension as well as recurrence of the incident SVT by day The CALISTO investigators also noticed the extremely low rate reported bleeding and concluded that such therapy was rational, was Analyse Thrombophlebitis, flexible, effective, was Analyse Thrombophlebitis, and durable after cessation of the fondaparinux therapy.

One must be mindful that many of at-risk patients with a clinical diagnosis of SVT in their practice may be the ones excluded from most reports, implying that, in one's clinic, results might actually be significantly better yet sparing the expenses of laboratory testing or serial ultrasound examination in most SVT patients. One can now logically argue to preemptively treat patients, even if one perceives thrombosis is limited to the SVT stage.

VTE risks are higher for an untoward event in untreated patients, especially if their history suggests a significant personal or family VTE history, the presence or likelihood of underlying malignancy, or limited cardiovascular and respiratory reserve to such an extent that even a modest-sized PE may prove fatal.

We can risk-stratify our patients using current risk factors and knowledge of SVT as herein reviewed to Genetische Natalia Stepanova Varizen Thrombophlebitis whether systemic anticoagulant therapy is warranted. Admittedly, was Analyse Thrombophlebitis, with the exception of the Decousus et al report, 34 there are no high-grade evidence-based data currently available, was Analyse Thrombophlebitis.

Clinical considerations include the size of the thrombosed vessel, whether there was provocation, history of recurrence, history of prior treatment with anticoagulant therapy for VTE, family history, known thrombophilia, and overall perceived risk of a PE to this patient. The gestalt of the situation will typically allow one to decide for or against systemic anticoagulant therapy.

Consider a patient who had dental work and peripheral intravenous lines inserted into the veins of the back of his hand resulting in a thrombosis extending into his veins of the upper arm. If was Analyse Thrombophlebitis were known to have had a prior DVT and administration of anticoagulants for a year after a PE related to a broken leg 10 years ago, I would consider anticoagulant therapy for him for the next 3 months, based on my perception was Analyse Thrombophlebitis he is hypercoagulable and this small untreated thrombus could provoke a VTE Genetische Analyse Thrombophlebitis in such a patient.

In a second scenario, was Analyse Thrombophlebitis, an obese year-old woman with active inflammatory bowel was Analyse Thrombophlebitis develops a cm, palpable, tender, warm cord in her left GSV as her initial experience with thrombosis after several weeks of Genetische Analyse Thrombophlebitis total bed rest.

I would prescribe 6 months of anticoagulant therapy or even longer should her inflammatory bowel disease Genetische Analyse Thrombophlebitis active. In the routine treatment of patients with DVT lacking symptoms of PE, imaging studies to document the presence of PE are generally not held as necessary as the decision to treat with systemic anticoagulant therapy is sufficient with DVT alone.

Accordingly, I do not routinely repeatedly and serially and exhaustively image patients with SVT as I hold that those patients have reason enough to be treated with systemic anticoagulation, saving a significant amount of time and expense. Such an approach can be modified if symptoms so suggest. Similarly, I would perform laboratory testing for thrombophilia only in situations that I thought might change the type of therapy, the duration of the therapy, or if such would have any clinical impact on the patient or especially his family members, was Analyse Thrombophlebitis.

One anxiously awaits randomized was Analyse Thrombophlebitis trials to document the validity of these suggestions, but until that time it seems efficacious and safe to regard the majority of SVTs, particularly those of the long saphenous vein, was Analyse Thrombophlebitis, as being of potential danger and worthy of anticoagulant Genetische Analyse Thrombophlebitis.

Was Analyse Thrombophlebitis do not retain Genetische Analyse Thrombophlebitis email addresses. Skip to main content. Search for this Genetische Analyse Thrombophlebitis.

Leading the way in experimental and clinical research in hematology. Abstract Thrombosis of superficial veins has Genetische Analyse Thrombophlebitis been regarded as a benign disorder. What exactly is and is not SVT? A method of managing superficial thrombophlebitis. Diseases Genetische Analyse Thrombophlebitis the veins. A System of Practical Medicine. Anticoagulant drugs in the treatment of pulmonary embolism: Chest ; 6 suppl: Nomenclature of the veins of the lower limbs: J Vasc Surg ; 36 2: The superficial femoral vein: The superficial femoral vein [letter].

Venous thromboses at unusual sites. Consultative Hemostasis and Thrombosis. West J Med ;:


Was Analyse Thrombophlebitis Genetische Analyse Thrombophlebitis

Was Analyse Thrombophlebitis continuing to browse this site you agree to us using cookies as described in About Cookies. Although superficial thrombophlebitis of the upper extremity represents a frequent complication of intravenous catheters inserted was Analyse Thrombophlebitis the peripheral veins of the forearm or hand, no consensus exists on the optimal management of this condition in clinical practice.

To summarise the evidence from randomised clinical trials RCTs concerning the efficacy and safety of topical, oral or parenteral medical therapy of superficial thrombophlebitis of the upper extremity. Clinical trials registries were searched up to April RCTs comparing any topical, oral or parenteral medical treatment to no intervention or placebo, or comparing two different medical interventions e.

We extracted data on methodological quality, patient characteristics, interventions and outcomes, including improvement of signs and symptoms as the primary effectiveness outcome, and number of participants experiencing side effects of the study treatments as the primary safety outcome. We identified 13 studies participants. The evaluated treatment modalities consisted of a topical treatment 11 studiesan oral treatment 2 studies and a parenteral treatment 2 studies. Seven studies used a placebo or no intervention control group, whereas all others also or solely compared active treatment groups.

No study evaluated the effects of ice or the application of cold or hot bandages. Overall, the risk of bias in individual trials was moderate to high, although poor reporting hampered a full appreciation of the risk in most studies. The overall quality of the evidence for each of the outcomes varied from low to moderate mainly due to risk of bias and imprecision, with only single trials contributing to most comparisons, was Analyse Thrombophlebitis.

Data on primary outcomes improvement of signs and symptoms and side effects attributed to the study treatment could not be statistically pooled because of the between-study differences in comparisons, outcomes and type of instruments was Analyse Thrombophlebitis measure outcomes, was Analyse Thrombophlebitis.

An array of topical treatments, was Analyse Thrombophlebitis, such as heparinoid or diclofenac gels, was Analyse Thrombophlebitis pain compared to placebo or no intervention.

Compared to placebo, oral non-steroidal anti-inflammatory drugs reduced signs and symptoms intensity. Safety issues were reported sparsely and were not available for some interventions, such as notoginseny creams, parenteral low-molecular-weight heparin or defibrotide. Although several trials reported on adverse events with topical heparinoid creams, Essaven gel or phlebolan versus control, the trials were underpowered to adequately measure any differences between treatment modalities, was Analyse Thrombophlebitis.

Where reported, was Analyse Thrombophlebitis, adverse events with topical treatments consisted mainly of local allergic reactions. Only one study of 15 participants assessed thrombus extension and symptomatic venous thromboembolism with either oral non-steroidal anti-inflammatory drugs or low-molecular-weight heparin, and it reported no cases of either. No study reported on the development of suppurative phlebitis, was Analyse Thrombophlebitis, catheter-related bloodstream infections or quality of life.

The evidence about the treatment of acute infusion superficial thrombophlebitis is limited and of low quality. Data appear too preliminary to assess the effectiveness and safety of topical treatments, systemic anticoagulation or oral non-steroidal anti-inflammatory drugs.

Superficial thrombophlebitis is an inflammatory condition of the was Analyse Thrombophlebitis just below the surface of the skin. The development of superficial thrombophlebitis frequently complicates the insertion of needles into the veins for catheters to give medication or fluids in hospitalised patients.

The best treatment for these blood clots in the hands and arms remains unclear. While local treatment has the potential to improve the painful symptoms and patient discomfort, it may not prevent complications, including infection or the extension was Analyse Thrombophlebitis transit of the clot into the deep vein system.

In the current review, was Analyse Thrombophlebitis, which looked for studies up to Aprilwe identified 13 studies involving participants. Eleven studies evaluated topical treatments medication applied to the skintwo trials studied an oral treatment, was Analyse Thrombophlebitis, and two studies assessed a parenteral treatment via injection or infusion.

Seven studies used a control group that received no treatment or a placebo, whereas all others also or solely compared two active treatment groups. Overall, topical treatments resulted in a higher and faster improvement of the clinical signs and symptoms compared to placebo or no intervention.

Reporting on safety data was limited, with no available information on some treatments notoginseny creams, was Analyse Thrombophlebitis, parenteral low-molecular-weight heparin or defibrotide. Although some studies reported on harmful side effects with topical heparinoid creams, Was Analyse Thrombophlebitis gel or phlebolan, the trials were too small in size to adequately measure any differences between treatments. Reported side effects of topical treatments consisted mainly of local allergic reactions.

Only one study with 15 participants assessed anything other than Schaumsklerotherapie Krampf control of the condition. That study reported on extension of the clot or symptomatic venous thromboembolism when the blood clot breaks loose and travels in the blood streamobserving no cases when treated orally with non-steroidal anti-inflammatory drugs or with low-molecular-weight heparin.

Was Analyse Thrombophlebitis of the studies reported on the development of suppurative or septic phlebitis when pus is formed inside the vein or around the vein wall or bothwas Analyse Thrombophlebitis bloodstream infections or quality of life.

Some of the included studies may have been biased due to design limitations, was Analyse Thrombophlebitis, but we could not always assess this risk because the original researchers did was Analyse Thrombophlebitis always provide enough information to judge. The overall quality of the evidence for each of the outcomes varied from low to moderate, mainly because the studies had design flaws or were very small. We could not analyse data on primary outcomes together because the trials examined different Jersey mit Krampfadern in den Beinen, in different ways, looking at different outcomes.

In short, the evidence about the treatment of acute infusion superficial thrombophlebitis is limited and of low quality, and we do not have enough information to recommend the use of any of the treatments studied. Article first published online: By continuing to browse this site you agree to us using cookies as described in About Cookies Remove maintenance message. Go to old article view Comment.

Abstract Background Although superficial thrombophlebitis of the upper extremity represents a frequent complication of intravenous catheters inserted into the peripheral veins of the forearm or hand, no consensus exists on the optimal management was Analyse Thrombophlebitis this condition in clinical practice.

Objectives To summarise the evidence from randomised clinical trials RCTs concerning the efficacy and safety of topical, oral or parenteral medical therapy of superficial thrombophlebitis of the upper extremity. Selection criteria RCTs comparing any topical, oral or parenteral medical treatment to no intervention or placebo, or comparing two different medical interventions e. Data collection and analysis We extracted data on methodological quality, patient characteristics, interventions and outcomes, including improvement of signs and symptoms as the primary effectiveness outcome, and number of participants experiencing side effects of the study treatments as the primary safety outcome.

Main results We identified 13 studies participants, was Analyse Thrombophlebitis. Authors' conclusions The evidence about the treatment of acute infusion superficial thrombophlebitis is limited and of low quality, was Analyse Thrombophlebitis. Plain language summary Treatment for superficial infusion thrombophlebitis of the upper extremity Background Superficial thrombophlebitis is an inflammatory condition of the veins just below the surface of the skin.

Study characteristics and key results In the current review, which looked for studies up to Aprilwe identified 13 studies involving participants. Quality of the evidence Some of the included studies may have been biased due to design limitations, but we could not always assess this risk because the original researchers did not always provide enough information to judge, was Analyse Thrombophlebitis.

Continue reading full article. Editorial Group Cochrane Vascular Group. Number of times cited: Close article support pane.


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